An AI-designed drug, rentosertib, and why Insilico is a company to keep on your radar

On average, it takes more than a decade for a drug to get from the lab to a patient.

Insilico Medicine did something different: one algorithm chose the target and another designed the molecule.

The compound is called INS018_055 and it blocks a protein called TNIK, which is implicated in fibrosis—that internal scarring that hardens organs and causes them to lose function.

In the paper published in Nature Biotechnology, they describe how they identified the target using artificial intelligence, generated the compound, and reduced fibrosis in animal models of various organs.

Afterward, they tested it in a first trial with 78 healthy volunteers, randomized and placebo-controlled. They measured safety, tolerance, and how it behaves in the body. Nothing else.

That is all it proves for now: that the process works, not that the drug works in sick people.

From target discovery to the preclinical candidate, it took about eighteen months. Its efficacy in patients remains to be confirmed.

What seems relevant to me is not the pill. It is the speed.

If that way of searching for targets becomes consolidated, the bottleneck of longevity will stop being the lack of ideas and will become clinical validation.

That is why Insilico is on my radar as an investor. And that is why I continue measuring my biomarkers every year.

Because while science advances, what decides how you age today is still your muscle mass, your sleep, and your glucose.

AI will shorten timelines. Your body is not waiting for them to arrive.

Your 1% improvement for today.

Write down three biomarkers you have never measured before and request the blood work this week. Without your own data, any scientific breakthrough arrives too late for you.

This is what I cover in the Longevity Workshop and Private Longevity WhatsApp Group: While AI accelerates drugs that do not yet exist, in my workshop and WhatsApp group I teach you which biomarkers to measure and how to interpret them now.

Remember that I now only sell ONE access to the Longevity Workshop and Private Longevity WhatsApp Group per day.

The price is set by a Dutch auction.

It goes down throughout the day.

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