Genetic editing for skin: what is already possible and what is coming

«Take care of the minutes, and the hours will take care of themselves.»

– Lord Chesterfield

We dream of editing the DNA of our skin. And in the meantime, we damage it every morning without even realizing it.

Imagine being able to erase from your skin the damage left by thirty summers of sun.

That is what many think of when they hear about CRISPR.

CRISPR is a tool that locates a specific piece of DNA and cuts or corrects it. Like the find and replace function in a word processor, but for your genes.

The big news right now is lonvo-z, from Intellia. The FDA will decide on March 10, 2027, whether to approve the first CRISPR therapy that edits genes inside the body.

In its phase 3 trial, attacks of hereditary angioedema dropped by 87% compared to placebo.

It works because it shuts down a single gene in the liver, an organ that is easy to reach.

The skin is a different story.

There are already gene therapies approved for a severe skin disease, known as butterfly skin, and research is underway to correct its gene with CRISPR.

But for aging, there is nothing. Sun damage is not one broken gene: it is millions of small errors spread across millions of cells.

What does exist is repair. Your cells correct a good part of the damage the sun leaves on their DNA every single day.

In a trial with 386 people who had already had skin cancer, taking nicotinamide, a form of vitamin B3, for one year reduced new non-melanoma skin cancers by 23%.

The caveat: they were high-risk individuals and the effect disappeared when they stopped taking it. It is not a rejuvenating pill nor something everyone should take.

Genetic skin editing will arrive, but it will be a long time coming.

The future of your skin is not in a laboratory. It is in what you do every morning in front of the mirror.

In the meantime, you can already slow down the aging of your skin with a protocol that has evidence: less damage each day and more room for your cells to repair.

Your 1% improvement today. Compound interest that adds up.

Put on sunscreen every morning on your face, neck, and the backs of your hands, even in winter. And if you have had skin cancer, ask your dermatologist about nicotinamide.

This is what I cover in the Gray Hair and Wrinkles Protocol: how I reduce the damage the sun leaves on the skin and the follicle, and what I do every day so that there is less to repair.

Remember that I now sell only ONE access to the Gray Hair and Wrinkles Protocol per day.

The price is set by a Dutch auction.

It goes down throughout the day.

→ See the current price of the Gray Hair and Wrinkles Protocol